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Dietary modifications of lipid metabolism in canine plasma during gestation, lactation, and the neonatal period

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dc.creator Wright, Angela Shanna en_US
dc.date.accessioned 2012-06-07T23:21:59Z
dc.date.available 2012-06-07T23:21:59Z
dc.date.created 2004 en_US
dc.date.issued 2012-06-07
dc.identifier.uri http://hdl.handle.net/1969.1/ETD-TAMU-2004-THESIS-W7 en_US
dc.description Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to digital@library.tamu.edu, referencing the URI of the item. en_US
dc.description Includes bibliographical references (leaves 54-60). en_US
dc.description Issued also on microfiche from Lange Micrographics. en_US
dc.description.abstract A study was done to investigate and better understand dietary modifications of canine lipid metabolism during gestation, lactation, and the neonatal period. Sexually intact, clinically normal female dogs were bred to the same sire and divided into four groups based on the diet composition they consumed while on the study. The diets were identical, except for varying amounts of alpha-linolenic acid relative to n-3 long chain polyunsaturated fatty acids. The fat sources were tallow (Lo/Lo), linseed oil (Hi/Lo), low (Lo/Mod) or high (Lo/Hi) menhaden fish oil. Plasma was collected on days 0, 3, 7, 14, 28, 42, and 56 of gestation, days 10 and 28 of lactation, and days 4, 10, 16, 28, 70, and 84 of the neonatal period. Electrophoresis was run on these samples, as well as total cholesterol, free cholesterol, and triglyceride analyses. Both time and diet effects in plasma lipids were observed during gestation and lactation of the bitches and as during the perinatal period of the puppies. During gestation, total plasma cholesterol was elevated in the later stages compared to earlier stages in all four groups of dogs . Also, both beta lipoprotein and alpha₂ lipoprotein fractions were increased during this time in all groups. The two lactation samples were compared to the nonpregnant state. Similar to gestation, during lactation, there was a decrease in total plasma cholesterol concentrations and alpha lipoprotein fractions compared to the nonpregnant state. Also during lactation, free cholesterol concentrations were lower than those of the nonpregnant state. In the puppy, total plasma cholesterol and beta-lipoprotein-cholesterol were elevated on days 4 and 10. These cholesterol concentrations decreased as the puppy aged. Both plasma cholesterol and triglyceride concentrations were lower in dogs fed the diets containing the fish oil diets. This data leads us to believe that lipid metabolism alterations must occur in order to maintain proper homeostasis for both the mother and her offspring. en_US
dc.format.medium electronic en_US
dc.format.mimetype application/pdf en_US
dc.language.iso en_US en_US
dc.publisher Texas A&M University en_US
dc.rights This thesis was part of a retrospective digitization project authorized by the Texas A&M University Libraries in 2008. Copyright remains vested with the author(s). It is the user's responsibility to secure permission from the copyright holder(s) for re-use of the work beyond the provision of Fair Use. en_US
dc.subject nutrition. en_US
dc.subject Major nutrition. en_US
dc.title Dietary modifications of lipid metabolism in canine plasma during gestation, lactation, and the neonatal period en_US
dc.type Thesis en_US
thesis.degree.discipline nutrition en_US
thesis.degree.name M.S. en_US
thesis.degree.level Masters en_US
dc.type.genre thesis
dc.type.material text en_US
dc.format.digitalOrigin reformatted digital en_US


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